Diet-Microbiota Interactions: A New Approach to Personalized Nutrition

Authors

  • Hasani-Ranjbar, Shirin Professor, Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  • Larijani, Bagher Professor, Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  • Malmir, Hanieh MSc in Nutrition, Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  • Ejtahed, Hanieh-Sadat Assistant Professor, Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  • Esmaillzadeh, Ahmad Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  • Hasanzad, Mandana Associate Professor, Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  • Soroush, Ahmad-Reza Professor, Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
Abstract:

 Personalized nutrition is a new approach in medical sciences that is based on genetic profile, individual needs, and environmental conditions considering health status and chronic diseases of every person. Studies have shown that genetic differences cannot solely justify various responses to medications and diets, and other important factors including gut microbiota are also involved. Human body hosts an active and dynamic ecosystem composed of a large number of microorganisms consisting of genes about ten times more than the human genome. Gut microbiota interacts with the human body through releasing metabolites such as short-chain fatty acids and secondary bile acids and fermentation products such as kynurenine, indoles and indole derivatives, tryptophan, serotonin, histamine, and dopamine. Body weight, metabolic rate, and health and diseases are formed as a result of these interactions.

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Journal title

volume 31  issue 193

pages  140- 151

publication date 2021-01

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